Pathways
MSP-RON Signaling
Description:
MSP (Macrophage-Stimulating Protein) also known as HGFL (Hepatocyte Growth Factor–Like Protein,) is a plasminogen-like growth factor that mediates its biological activities by activating the receptor tyrosine kinase RON also known as MSTR1, (Macrophage Stimulating Receptor-1), a member of the MET proto-oncogene family . The alpha-chain of MSP consists of an N-terminal PAN module followed by four kringle domains and is disulfide linked to the trypsin-like beta-chain. This protein is secreted as an inactive sin...
References:
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Proteolytic activation of pro-macrophage-stimulating protein by hepsin.
Mol Cancer Res. 2011 Sep;9(9):1175-86. doi: 10.1158/1541-7786.MCR-11-0004. Epub 2011 Aug 29. -
Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2expression in murine macrophages.
J Biol Chem. 2002 Oct 11;277(41):38104-10. Epub 2002 Aug 12. -
The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity.
J Immunol. 2008 Aug 15;181(4):2303-10. -
MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
Nat Rev Cancer. 2013 Jul;13(7):466-81. doi: 10.1038/nrc3545. Review.
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