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MSP-RON Signaling


MSP (Macrophage-Stimulating Protein) also known as HGFL (Hepatocyte Growth Factor–Like Protein,) is a plasminogen-like growth factor that mediates its biological activities by activating the receptor tyrosine kinase RON  also known as MSTR1, (Macrophage Stimulating Receptor-1), a member of the MET proto-oncogene family . The alpha-chain of MSP consists of an N-terminal PAN module followed by four kringle domains[...]




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