Pathways
MTOR Pathway
Description:
mTOR (Mammalian Target of Rapamycin) is a 289-kDa serine/threonine protein kinase and a member of the PIKK (Phosphatidylinositol 3-Kinase-related Kinase) family. The protein consists of a Catalytic Kinase domain, an FRB (FKBP12–Rapamycin Binding) domain, a putative Auto-inhibitory domain (Repressor domain) near the C-terminus and up to 20 tandemly repeated HEAT motifs at the Amino terminus, as well as FAT (FRAP-ATM-TRRAP) and FATC (FAT C-terminus) domains. The C-terminus of TOR is highly homologous to the catalytic doma...
References:
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mTOR signaling in growth control and disease.
Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017. Review. -
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.
Nat Cell Biol. 2013 Jun;15(6):555-64. doi: 10.1038/ncb2763. Review. -
Targeting the PI3-kinase/Akt/mTOR signaling pathway.
Surg Oncol Clin N Am. 2013 Oct;22(4):641-64. doi: 10.1016/j.soc.2013.06.008. Epub 2013 Aug 6. Review. -
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
J Biol Chem. 2014 Aug 15;289(33):22583-8. doi: 10.1074/jbc.R114.566091. Epub 2014 Jul 2. Review.
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