Pathways
Mucosal Healing through Trefoil Factors
Description:
Epithelial continuity depends on a family of small, yet abundant, secreted proteins the TFFs (Trefoil Factors). TFFs are considered as 'Rapid Response' agents to mucosal injury; with up-regulation of expression in the early stages of mucosal repair. These peptides are involved in mucosal maintenance and repair through motogenic and anti-apoptotic activities. They also function as scatter factors, pro-invasive and angiogenic agents. TFFs are connected with multiple oncogenic pathways. As a consequence, the TFF signalin...
References:
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Trefoil factor family (TFF) peptides and cancer progression.
Peptides. 2004 May;25(5):885-98. -
Trefoil factors: initiators of mucosal healing.
Nat. Rev. Mol. Cell Biol. 2003 Sep;4(9):721-32. -
Isolation and characterization of putative trefoil peptide receptors.
Regul. Pept. 2000 Jun 30;90(1-3):61-8. -
Trefoil peptides.
Gut. 1999 Jun;44(6):890-5.
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