Pathways
Murine mSP-STK Signaling
Description:
Immune and inflammatory responses are rightly regulated to maintain a homoeostatic balance between an effective immune response and tissue damage to the host. Nitric Oxide is the principal mediator of many of the cytokine-inducible macrophage activities during a normal cell-mediated immune response. STK (Stem Cell-Derived Tyrosine Kinase), the murine homolog of the human RON (RON Protein Tyrosine Kinase/ Receptor d’origine nantais), is expressed on murine resident peritoneal macrophages. The ligand for STK, MSP (Ma...
References:
-
Macrophage stimulating protein is a novel neurotrophic factor.
Mol Biol Cell. 2001 May;12(5):1341-52. -
Proteolytic activation of pro-macrophage-stimulating protein by hepsin.
Mol Cancer Res. 2011 Sep;9(9):1175-86. doi: 10.1158/1541-7786.MCR-11-0004. Epub 2011 Aug 29. -
Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide.
J Immunol. 2004 Feb 1;172(3):1825-32. -
Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages.
J. Biol. Chem. 2002 Oct 11;277(41):38104-10.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions