c-Myc and Apoptosis

Description:

Many proto-oncogenes participate in the regulation of apoptosis and closely intertwined with their actions are various growth factors and other genes that participate in the control of cellular growth. The proto-oncogene c-Myc encodes a transcription factor c-Myc that plays a critical role in multiple cellular processes including cell growth, proliferation, differentiation, and apoptosis. Expression of c-Myc is rapidly induced by mitogens and is down regulated during differentiation. c-Myc activity...

References:

MYC oncogenes and human neoplastic disease.
Nesbit CE, Tersak JM, Prochownik EV.
Oncogene. 1999 May 13; 18(19): 3004-16. Review.
c-Myc-induced sensitization to apoptosis is mediated through Cytochrome c release.
Juin P, Hueber AO, Littlewood T, Evan G.
Genes Dev. 1999 Jun 1; 13(11): 1367-81.
Proliferation, cell cycle and apoptosis in cancer.
Evan GI, Vousden KH.
Nature. 2001 May 17; 411(6835): 342-8. Review.
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.
Soengas MS, Alarcon RM, Yoshida H, Giaccia AJ, Hakem R, Mak TW, Lowe SW.
Science. 1999 Apr 2; 284(5411): 156-9.

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Pathways

c-Myc and Apoptosis

Description:

References:

MYC oncogenes and human neoplastic disease.

c-Myc-induced sensitization to apoptosis is mediated through Cytochrome c release.

Proliferation, cell cycle and apoptosis in cancer.

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

Databases

Tools

Institutional License

Pathways

c-Myc and Apoptosis

Description:

References:

MYC oncogenes and human neoplastic disease.

c-Myc-induced sensitization to apoptosis is mediated through Cytochrome c release.

Proliferation, cell cycle and apoptosis in cancer.

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

Databases

Tools

Institutional License

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