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Mycothiol metabolism in S. avermitilis


Soil-inhabiting species of Streptomyces are Gram-positive filamentous bacteria having a complex life cycle that begins with spore germination to form branched multinucleoid vegetative hyphae. The subsequent differentiation process results in formation of erect sporogenic aerial hyphae, followed by chains of unigenomic spores1. During the initiation of morphological differentiation, most Streptomyces species produce bioactive secondary metabolites, including a variety of many important antibiotics with antimicrobial, an...




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