Pathways
NANOG in Mammalian ESC Pluripotency
Description:
ESCs (Embryonic stem cells) are Pluripotent cells derived from the ICM (Inner Cell Mass) of Blastocyst-stage embryos. These cells have two distinctive properties: an unlimited capacity for Self-renewal and Pluripotency. The capability for Self-renewal and the Pluripotency of ESCs seem to be under the control of multiple transcriptional factors, most common among them being Nanog (Nanog homeobox), Oct4 (Octamer Binding Transcription Factor-4) and SOX2 (SRY (Sex Determining Region-Y) Box-2). Functi...
References:
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Transcriptional dynamics of the embryonic stem cell switch.
PLoS Comput Biol. 2006 Sep 15;2(9):e123. -
Core transcriptional regulatory circuitry in human embryonic stem cells.
Cell. 2005 Sep 23;122(6):947-56. -
Identification of a putative transactivation domain in human Nanog.
Exp Mol Med. 2005 Jun 30;37(3):250-4. -
Nanog and transcriptional networks in embryonic stem cell pluripotency.
Cell Res. 2007 Jan;17(1):42-9. Review.
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