Pathways
Netrin Signaling
Description:
Netrin1 (NTN1) Netrin1 is an evolutionarily conserved signaling protein , which functions as a common cue for axonal guidance and vascular patterning and is responsible for integrating regulatory cues from retinal neurons, glia and immune cells.Netrin1 deficiency may result in shunting of metabolic resources to optimize cell survival in viable retinal cells (Ref.1). Exposure to Netrin1 may lead to chemoattraction or chemoreulsion of an axon. The switching responses between attraction and repulsion are dependent on severa...
References:
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Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration.
PLoS One. 2015 May 7;10(5):e0125548. doi: 10.1371/journal.pone.0125548. eCollection 2015. -
Revisiting Netrin-1: One Who Guides (Axons).
Front Cell Neurosci. 2018 Jul 31;12:221. doi: 10.3389/fncel.2018.00221. eCollection 2018. Review. -
Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in the embryonic spinal cord.
J Neurosci. 2003 May 1; 23(9):3735-44. -
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.
Nature. 2004 Sep 2; 431(7004):80-4.
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