Pathways
Neuropathic Pain-Signaling in Dorsal Horn Neurons
Description:
Inflammation is the process by which an organism responds to tissue injury involving both immune cell recruitment and mediator release. Diverse causes of neuropathic pain are associated with excessive inflammation in both the peripheral and central nervous system which may contribute to the initiation and maintenance of persistent pain. Chemical mediators, such as cytokines, chemokines, and lipid mediators, released during an inflammatory response have the undesired effect of sensitizing and stimulating nociceptors, their cen...
References:
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Neuroinflammation and the generation of neuropathic pain.
Br J Anaesth. 2013 Jul; 111(1):26-37. doi: 10.1093/bja/aet128. Review. -
Neuropathic pain and cytokines: current perspectives.
J Pain Res. 2013 Nov 21;6:803-14. doi: 10.2147/JPR.S53660. -
Neurotrophins and Neuropathic Pain: Role in Pathobiology.
Molecules. 2015 Jun 9; 20(6):10657-88. doi: 10.3390/molecules200610657. Review. -
Neuropathic pain: mechanisms and their clinical implications.
BMJ. 2014 Feb 5;348:f7656. doi: 10.1136/bmj.f7656. Erratum in: BMJ. 2014;348:g2323.
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