Pathways
NF-KappaB Activation by EBV
Description:
Epstein-Barr virus (EBV) is a gamma-herpesvirus that infects more than 90% of people worldwide, is the etiologic agent of infectious mononucleosis, and is associated with multiple human malignancies, primarily of lymphoid and epithelial cell origin, including Burkitt’s lymphoma, post-transplant lymphoma, AIDS-associated lymphomas, Hodgkin’s disease, T-Cell lymphoma, NPC (Nasopharyngeal Carcinoma), parotid gland carcinoma, and gastric carcinoma. EBV-encoded RNAs (EBERs) are the most abundant viral transcripts in latently EBV-...
References:
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NF-êB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Viruses. 2013 Jun 21;5(6):1587-606. doi: 10.3390/v5061587. Review. -
EBV LMP1: New and shared pathways to NF-êB activation.
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2188-9. doi: 10.1073/pnas.1121357109. Epub 2012 Feb 2. No abstract available. -
Canonical NF-kappaB activation is essential for Epstein-Barr virus latent membrane protein 1 TES2/CTAR2 gene regulation.
J Virol. 2011 Jul;85(13):6764-73. doi: 10.1128/JVI.00422-11. Epub 2011 May 4. -
Role of the immunoreceptor tyrosine-based activation motif of latent membrane protein 2A (LMP2A) in Epstein-Barr virus LMP2A-induced cell transformation.
J Virol. 2014 May;88(9):5189-94. doi: 10.1128/JVI.03714-13. Epub 2014 Feb 19.
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