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NF-kappaB Activation by Viruses


The transcription factor nuclear factor-kappa B (NF-kappaB) plays a fundamental role in the innate antiviral response, acting as a hub network in signal transduction that connects cellular sensors of viral invasion with effector mechanisms of antiviral defence (Ref.1). NF-kappaB pathway appears to be an attractive target for common human viral pathogens. Many viruses, including several human pathogens such as HIV1, the human T-cel[...]




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