NF-kappaB Activation by Viruses

Description:

The transcription factor nuclear factor-kappa B (NF-kappaB) plays a fundamental role in the innate antiviral response, acting as a hub network in signal transduction that connects cellular sensors of viral invasion with effector mechanisms of antiviral defence (Ref.1). NF-kappaB pathway appears to be an attractive target for common human viral pathogens. Many viruses, including several human pathogens such as HIV1, the human T-cell leukemia virus HTLV1, Influenza virus, hepatitis B and C viruses, Adenovirus, Kaposi’s sa...

References:

HSV-1-induced activation of NF-κB protects U937 monocytic cells against both virus replication and apoptosis.
Marino-Merlo F, Papaianni E, Medici MA, Macchi B, Grelli S, Mosca C, Borner C, Mastino A.
Cell Death Dis. 2016 Sep 1;7(9):e2354. doi: 10.1038/cddis.2016.250.
NF-kappaB and virus infection: who controls whom.
Santoro MG, Rossi A, Amici C.
EMBO J. 2003 Jun 2;22(11):2552-60. Review.
Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65.
Fiume G, Vecchio E, De Laurentiis A, Trimboli F, Palmieri C, Pisano A, Falcone C, Pontoriero M, Rossi A, Scialdone A, Fasanella Masci F, Scala G, Quinto I.
Nucleic Acids Res. 2012 Apr;40(8):3548-62. doi: 10.1093/nar/gkr1224. Epub 2011 Dec 19.
NF-κB as a target for oncogenic viruses.
Sun SC, Cesarman E.
Curr Top Microbiol Immunol. 2011;349:197-244. doi: 10.1007/82_2010_108. Review.

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Pathways

NF-kappaB Activation by Viruses

Description:

References:

HSV-1-induced activation of NF-κB protects U937 monocytic cells against both virus replication and apoptosis.

NF-kappaB and virus infection: who controls whom.

Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65.

NF-κB as a target for oncogenic viruses.

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Institutional License

Pathways

NF-kappaB Activation by Viruses

Description:

References:

HSV-1-induced activation of NF-κB protects U937 monocytic cells against both virus replication and apoptosis.

NF-kappaB and virus infection: who controls whom.

Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65.

NF-κB as a target for oncogenic viruses.

Databases

Tools

Institutional License

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