NF-KappaB Family Pathway

Description:

NF-KappaB (Nuclear Factor-KappaB) is a heterodimeric protein composed of different combinations of members of the Rel family of transcription factors. The Rel/ NF-KappaB family of transcription factors are involved mainly in stress-induced, immune, and inflammatory responses. In addition, these molecules play important roles during the development of certain hemopoietic cells, keratinocytes, and lymphoid organ structures. More recently, NF-KappaB family members have been implicated in neoplastic progression and the formation ...

References:

The NF-kappaB family of transcription factors and its regulation.
Oeckinghaus A, Ghosh S.
Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000034. doi: 10.1101/cshperspect.a000034. Review.
The Regulation of NF-κB Subunits by Phosphorylation.
Christian F, Smith EL, Carmody RJ.
Cells. 2016 Mar 18;5(1). pii: E12. doi: 10.3390/cells5010012. Review
IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.
Scheidereit C.
Oncogene. 2006 Oct 30;25(51):6685-705. Review.
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.
Park B, Sung B, Yadav VR, Chaturvedi MM, Aggarwal BB.
Biochem Pharmacol. 2011 Nov 1;82(9):1134-44. doi: 10.1016/j.bcp.2011.07.062. Epub 2011 Jul 27. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:141

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Pathways

NF-KappaB Family Pathway

Description:

References:

The NF-kappaB family of transcription factors and its regulation.

The Regulation of NF-κB Subunits by Phosphorylation.

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.

Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.

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Pathways

NF-KappaB Family Pathway

Description:

References:

The NF-kappaB family of transcription factors and its regulation.

The Regulation of NF-κB Subunits by Phosphorylation.

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.

Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.

Databases

Tools

Institutional License

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