Pathways
NF-KappaB Orthologue in Fruitfly (Drosophila melanogaster)
.jpg "NF-KappaB Orthologue in Fruitfly (Drosophila melanogaster)")
Description:
NF-KappaB (Nuclear factor-KappaB)/Rel proteins are dimeric, sequence-specific transcription factors involved in the activation of an exceptionally large number of genes in response to inflammation, viral and bacterial infections, and other stressful situations requiring rapid reprogramming of gene expression. NF-kappB pathway is crucial for the regulation of immune responses, inflammation, and stress responses. Rel/NF-KappaB transcription factors include a collection of proteins, conserved from the fruit fly Drosophila melano...
References:
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The NF-kappaB family of transcription factors and its regulation.
Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000034. doi: 10.1101/cshperspect.a000034. Review. -
NF-êB/Rel proteins and the humoral immune responses of Drosophila melanogaster.
Curr Top Microbiol Immunol. 2011;349:25-60. doi: 10.1007/82_2010_107. Review. -
The Drosophila Toll signaling pathway.
J Immunol. 2011 Jan 15;186(2):649-56. doi: 10.4049/jimmunol.1002302. Review. -
The Drosophila IMD pathway in the activation of the humoral immune response.
Dev Comp Immunol. 2014 Jan;42(1):25-35. doi: 10.1016/j.dci.2013.05.014. Epub 2013 May 27. Review.
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