Pathways
NFAT in Immune Response
Description:
Antigenic stimulation of lymphocytes and other cells of the immune system initiates a complex series of intracellular signal transduction pathways that lead to the expression of a panel of immunoregulatory genes, whose function is critical to the initiation and coordination of the immune response. NFATs (Nuclear Factors of Activated T-Cells), a family of transcription factors expressed both inside and outside of diverse cell types of the immune system, play a pivotal role in the process. Originally described in T-Cells, ...
References:
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NFAT proteins: key regulators of T-cell development and function.
Nat Rev Immunol. 2005 Jun;5(6):472-84. Review. -
Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling.
Mol Cells. 2004 Aug 31;18(1):1-9. Review. -
Ca2+/calcineurin signalling in cells of the immune system.
Biochem Biophys Res Commun. 2003 Nov 28;311(4):1117-32. -
Transcriptional regulation by calcium, calcineurin, and NFAT.
Genes Dev. 2003 Sep 15;17(18):2205-32. Review.
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