Pathways
NFAT Signaling and Lymphocyte Interactions
Description:
The optimum functioning of the immune system is crucial for human survival. The invading pathogens are encountered by the cells of the immune system, which include T-Cells, B-Cells, macrophages, neutrophils, basophils, eosinophils, endothelial cells, or mast cells. These cells have distinct roles in the immune system, and cell-to-cell communication among these cells is an indispensable prerequisite for the stimulation of the optimum immune response. In the process, cytokines serve as signal molecules for communication that...
References:
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NFAT control of innate immunity.
Blood. 2012 Aug 16;120(7):1380-9. doi: 10.1182/blood-2012-02-404475. Epub 2012 May 18. Review. -
NFAT signaling: choreographing the social lives of cells.
Cell. 2002 Apr; 109 Suppl: S67-79. Review. -
Expression of the transcription factor NFAT2 in human neutrophils: IgE-dependent, Ca2+- and calcineurin-mediated NFAT2 activation.
J Cell Sci. 2007 Jul 15;120(Pt 14):2328-37. -
Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway.
J Biol Chem. 2003 May 9; 278(19): 16797-801. Epub 2003 Mar 03.
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