Pathways
NGF Pathway
Description:
One of the most fundamental issues in current biology is how to maintain the critical balance between cell survival and death, both during development and in adulthood. Unrestrained cell division and survival leads to various forms of tumor, while excessive or premature cell death may lead to a variety of diseases such as Alzheimer's, Parkinson's and Multiple Sclerosis. In the nervous system, a family of Neurotrophins, which includes NGF (Nerve Growth Factor), BDNF (Brain Derived Neurotrophic Factor), NT3 (Neurotrophi...
References:
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Biogenesis and function of the NGF/TrkA signaling endosome.
Int Rev Cell Mol Biol. 2015; 314:239-57. doi: 10.1016/bs.ircmb.2014.10.002. Epub 2014 Nov 18. Review. -
Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a newplayer.
Front Mol Neurosci. 2014 May 14; 7:39. doi: 10.3389/fnmol.2014.00039. eCollection 2014. Review. -
The nerve growth factor signaling and its potential as therapeutic target for glaucoma.
Biomed Res Int. 2014; 2014:759473. doi: 10.1155/2014/759473. Epub 2014 Aug 31. Review. -
The effect of antenatal depression and selective serotonin reuptake inhibitor treatment on nerve growthfactor signaling in human placenta.
PLoS One. 2015 Jan 22; 10(1):e0116459. doi: 10.1371/journal.pone.0116459. eCollection 2015.
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