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Pathways

NGR-p75(NTR)-Mediated Signaling

Description:

Axon regeneration is arrested in the injured CNS (Central Nervous System) by axon growth-inhibitory ligands expressed in oligodendrocytes/myelin and reactive astrocytes in the lesion and by fibroblasts in scar tissue. Growth cone receptors bind inhibitory ligands, activating a Rho-family GTPase intracellular signaling pathway that disrupts the actin cytoskeleton inducing growth cone collapse/repulsion. The known inhibitory ligands include Eph (Ephrins) expressed on astrocyte/fibroblast membranes; the myelin/oligodendrocyte-de...

References:

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