Pathways
NGR-p75(NTR)-Mediated Signaling
-Mediated Signaling.jpg "NGR-p75(NTR)-Mediated Signaling")
Description:
Axon regeneration is arrested in the injured CNS (Central Nervous System) by axon growth-inhibitory ligands expressed in oligodendrocytes/myelin and reactive astrocytes in the lesion and by fibroblasts in scar tissue. Growth cone receptors bind inhibitory ligands, activating a Rho-family GTPase intracellular signaling pathway that disrupts the actin cytoskeleton inducing growth cone collapse/repulsion. The known inhibitory ligands include Eph (Ephrins) expressed on astrocyte/fibroblast membranes; the myelin/oligodendrocyte-de...
References:
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Myelin-associated inhibitors in axonal growth after CNS injury.
Curr Opin Neurobiol. 2014 Aug;27:31-8. doi: 10.1016/j.conb.2014.02.012. Epub 2014 Mar 6 -
LINGO-1 and AMIGO3, potential therapeutic targets for neurological and dysmyelinating disorders?
Neural Regen Res. 2017 Aug;12(8):1247-1251. doi: 10.4103/1673-5374.213538. -
MAG, myelin and overcoming growth inhibition in the CNS.
Front Mol Neurosci. 2015 Sep 7;8:51. doi: 10.3389/fnmol.2015.00051. -
The Nogo-66 receptor: focusing myelin inhibition of axon regeneration.
Trends Neurosci. 2003 Apr; 26(4):193-8. Review.
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