Pathways
nNOS Signaling in Skeletal Muscle
Description:
NO (Nitric Oxide) is formed endogenously by a family of enzymes known as NOS (NO Synthases). The distribution of different isoforms of NOS is largely related to their respective functions. Three distinct isoforms of NOS have been identified: nNOS (also known as NOSI and NOS-1) being the isoform first found (and predominating) in neuronal tissue, iNOS (also known as NOSII and NOS-2) which is inducible in a wide range of cells and tissues and eNOS (also known as NOSIII and NOS-3) isoform first found in vascular endothelial cell...
References:
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Nitric oxide synthases: regulation and function.
Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d. doi: 10.1093/eurheartj/ehr304. Epub 2011 Sep 1. Review. -
Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.
Physiol Rev. 2016 Jan;96(1):253-305. doi: 10.1152/physrev.00007.2015. Review. -
No-dependent signaling pathways in unloaded skeletal muscle.
Front Physiol. 2015 Oct 31;6:298. doi: 10.3389/fphys.2015.00298. eCollection 2015. Review. -
Redox Control of Skeletal Muscle Regeneration.
Antioxid Redox Signal. 2017 Aug 10;27(5):276-310. doi: 10.1089/ars.2016.6782. Epub 2017 Feb 6. Review.
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