NTHi-Induced Signaling

Description:

Nontypeable Haemophilus influenzae (NTHi) organisms are small Gram-negative bacteria that colonize the upper respiratory tract of humans beginning at a very early age. NTHi is also a leading cause of otitis media (OM), sinusitis, and community-acquired pneumonia, often following viral respiratory infection. A rising proportion of otitis media caused by NTHi has been attributed to widespread use of the pneumococcal conjugate vaccine, which was introduced in the year 2000 and has reduced the incidence of resp...

References:

Immunogenicity of Nontypeable Haemophilus influenzae Outer Membrane Vesicles and Protective Ability in the Chinchilla Model of Otitis Media.
Winter LE, Barenkamp SJ.
Clin Vaccine Immunol. 2017 Oct 5;24(10). pii: e00138-17. doi: 10.1128/CVI.00138-17. Print 2017 Oct.
Non-typeable Haemophilus influenzae invasion and persistence in the human respiratory tract.
Clementi CF, Murphy TF.
Front Cell Infect Microbiol. 2011 Nov 18;1:1. doi: 10.3389/fcimb.2011.00001. eCollection 2011. Review.
Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation.
Xu X, Steere RR, Fedorchuk CA, Pang J, Lee JY, Lim JH, Xu H, Pan ZK, Maggirwar SB, Li JD.
PLoS One. 2011;6(11):e28216. doi: 10.1371/journal.pone.0028216. Epub 2011 Nov 23.
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
Zhang Y, Feng XH, Derynck R
Nature. 1998 Aug 27; 394(6696): 909-13. Erratum in: Nature 1998 Dec 3; 396(6710): 491

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Pathways

NTHi-Induced Signaling

Description:

References:

Immunogenicity of Nontypeable Haemophilus influenzae Outer Membrane Vesicles and Protective Ability in the Chinchilla Model of Otitis Media.

Non-typeable Haemophilus influenzae invasion and persistence in the human respiratory tract.

Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation.

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

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Institutional License

Pathways

NTHi-Induced Signaling

Description:

References:

Immunogenicity of Nontypeable Haemophilus influenzae Outer Membrane Vesicles and Protective Ability in the Chinchilla Model of Otitis Media.

Non-typeable Haemophilus influenzae invasion and persistence in the human respiratory tract.

Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation.

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

Databases

Tools

Institutional License

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