Nucleotide Excision Repair Pathway

Description:

Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky DNA lesions such as those formed by UV light, environmental mutagens, and some cancer chemotherapeutic adducts from DNA. Deficiencies in NER are associated with the extremely skin cancer-prone inherited disorder xeroderma pigmentosum. Although the core NER reaction and the factors that execute it have been known for some years, recent studies have led to a much more detailed understanding of the NER mechanism, how NER operates in the contex...

References:

Nucleotide excision repair in eukaryotes.
Schärer OD.
Cold Spring Harb Perspect Biol. 2013 Oct 1;5(10):a012609. doi: 10.1101/cshperspect.a012609. Review.
DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae.
Boiteux S, Jinks-Robertson S.
Genetics. 2013 Apr;193(4):1025-64. doi: 10.1534/genetics.112.145219. Review.
How do male germ cells handle DNA damage?
Olsen AK, Lindeman B, Wiger R, Duale N, Brunborg G.
Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):521-31. Review.
Disorders of nucleotide excision repair.
Rapin I.
Handb Clin Neurol. 2013;113:1637-50. doi: 10.1016/B978-0-444-59565-2.00032-0. Review.

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Pathways

Nucleotide Excision Repair Pathway

Description:

References:

Nucleotide excision repair in eukaryotes.

DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae.

How do male germ cells handle DNA damage?

Disorders of nucleotide excision repair.

Databases

Tools

Institutional License

Pathways

Nucleotide Excision Repair Pathway

Description:

References:

Nucleotide excision repair in eukaryotes.

DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae.

How do male germ cells handle DNA damage?

Disorders of nucleotide excision repair.

Databases

Tools

Institutional License

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