NUR77-Induced AICD in Macrophage

Description:

PCD (Programmed Cell Death) or Apoptosis, is a genetically regulated, self-destructive cellular process found in metazoans to eliminate individual cells when they are no longer needed in development, tissue remodeling, or immune regulation, as well as in various diseases. Macrophages are specialized phagocytes responsible for ingesting and digesting senescent, dead, and damaged cells in many tissues as well as microorganisms. These are regarded as very important players in innate immunity becau...

References:

Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.
Castro-Obregon S, Rao RV, del Rio G, Chen SF, Poksay KS, Rabizadeh S, Vesce S, Zhang XK, Swanson RA, Bredesen DE.
J Biol Chem. 2004 Apr 23;279(17):17543-53. Epub 2004 Feb 09.
Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells.
Crean D, Cummins EP, Bahar B, Mohan H, McMorrow JP, Murphy EP.
J Immunol. 2015 Aug 15;195(4):1436-48. doi: 10.4049/jimmunol.1402039. Epub 2015 Jul 6.
In vitro macrophage activation: A technique for screening anti-inflammatory, immunomodulatory and anticancer activity of phytomolecules.
Paradkar PH, Mishra LS, Joshi JV, Dandekar SP, Vaidya RA, Vaidya AB.
Indian J Exp Biol. 2017 Mar;55(3):133-41. Review.
Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues.
Herring JA, Elison WS, Tessem JS.
Cells. 2019 Nov 1;8(11). pii: E1373. doi: 10.3390/cells8111373. Review.

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Pathways

NUR77-Induced AICD in Macrophage

Description:

References:

Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.

Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells.

In vitro macrophage activation: A technique for screening anti-inflammatory, immunomodulatory and anticancer activity of phytomolecules.

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues.

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Institutional License

Pathways

NUR77-Induced AICD in Macrophage

Description:

References:

Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.

Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells.

In vitro macrophage activation: A technique for screening anti-inflammatory, immunomodulatory and anticancer activity of phytomolecules.

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues.

Databases

Tools

Institutional License

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