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NUR77 Signaling in T-Cell


In the immune system, thymus acts as a primary lymphoid organ within which T cells referred to as thymocytes mature. During T cell development in the thymus, immature thymocytes expressing self-reactive TCR (T-Cell Receptor) are eliminated from the developing T-cell repertoire by clonal deletion, or negative selection. This deletion is carried out by Apoptotic signals delivered to thymocytes whose TCR have a high affinity for Self-Antigen/MHC (Majo...




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