NUR77 Signaling in T-Cell

Description:

In the immune system, thymus acts as a primary lymphoid organ within which T cells referred to as thymocytes mature. During T cell development in the thymus, immature thymocytes expressing self-reactive TCR (T-Cell Receptor) are eliminated from the developing T-cell repertoire by clonal deletion, or negative selection. This deletion is carried out by Apoptotic signals delivered to thymocytes whose TCR have a high affinity for Self-Antigen/MHC (Majo...

References:

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain.
Thompson J, Winoto A.
J Exp Med. 2008 May 12;205(5):1029-36. doi: 10.1084/jem.20080101. Epub 2008 Apr 28.
Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion.
Fassett MS, Jiang W, D'Alise AM, Mathis D, Benoist C.
Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3891-6. doi: 10.1073/pnas.1200090109. Epub 2012 Feb 15.
Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues.
Herring JA, Elison WS, Tessem JS.
Cells. 2019 Nov 1;8(11). pii: E1373. doi: 10.3390/cells8111373. Review.
T Cells and Gene Regulation: The Switching On and Turning Up of Genes afteT Cell Receptor Stimulation in CD8 T Cells.
Conley JM, Gallagher MP, Berg LJ.
Front Immunol. 2016 Feb 29;7:76. doi: 10.3389/fimmu.2016.00076. eCollection 2016. Review.

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Pathways

NUR77 Signaling in T-Cell

Description:

References:

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain.

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion.

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues.

T Cells and Gene Regulation: The Switching On and Turning Up of Genes afteT Cell Receptor Stimulation in CD8 T Cells.

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Institutional License

Pathways

NUR77 Signaling in T-Cell

Description:

References:

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain.

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion.

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues.

T Cells and Gene Regulation: The Switching On and Turning Up of Genes afteT Cell Receptor Stimulation in CD8 T Cells.

Databases

Tools

Institutional License

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