Pathways
OX40 Pathway
Description:
OX40 is an approximately 50-kD transmembrane glycoprotein of 249 amino acids, with a 49 amino acid cytoplasmic tail and a 186 amino acid extracellular region. It is a member of the TNFR (tumor necrosis factor receptor) superfamily and has three complete and one truncated cysteine-rich domains. It is a T-Cell activator that is believed to promote the survival (and perhaps prolong the immune response) of CD4+ T cells at sites of inflammation (Ref.1). OX40’s ligand (OX40L, also known as gp34, CD252, TNFSF4...
References:
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Control of immunity by the TNFR-related molecule OX40 (CD134).
Annu Rev Immunol. 2010;28:57-78. doi: 10.1146/annurev-immunol-030409-101243. -
OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology.
Adv Immunol. 2010;105:63-98. doi: 10.1016/S0065-2776(10)05003-0. -
OX40, OX40L and Autoimmunity: a Comprehensive Review.
Clin Rev Allergy Immunol. 2016 Jun;50(3):312-32. doi: 10.1007/s12016-015-8498-3. -
Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival.
J Immunol. 2008 Jun 1;180(11):7240-8. doi: 10.4049/jimmunol.180.11.7240.
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