Oxidation of Odd-Chain Fatty Acid

Description:

Most fatty acids have even number of carbon atoms and are therefore completely converted to Acetyl-CoA. Some plants and marine organisms, however, synthesize fatty acids with an odd number of carbon atoms. The final round of Beta-Oxidation of these fatty acids forms Propionyl-CoA, which is converted to Succinyl-CoA for entry into the Citric Acid Cycle. Propionyl-CoA can be derived from breakdown of certain amino acids (Isoleucine, Valine and Methionine), but in mammalian cells these pathways exist in mitochondri...

References:

Effects of odd-numbered medium-chain fatty acids on the accumulation of long-chain 3-hydroxy-fatty acids in long-chain L-3-hydroxyacyl CoA dehydrogenase and mitochondrial trifunctional protein deficient skin fibroblasts.
Jones PM, Butt YM, Bennett MJ.
Mol Genet Metab. 2004 Feb; 81(2):96-9.
Propionyl-CoA carboxylase - A review.
Wongkittichote P, Ah Mew N, Chapman KA.
Mol Genet Metab. 2017 Dec;122(4):145-152. doi: 10.1016/j.ymgme.2017.10.002. Epub 2017 Oct 7.

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Pathways

Oxidation of Odd-Chain Fatty Acid

Description:

References:

Effects of odd-numbered medium-chain fatty acids on the accumulation of long-chain 3-hydroxy-fatty acids in long-chain L-3-hydroxyacyl CoA dehydrogenase and mitochondrial trifunctional protein deficient skin fibroblasts.

Propionyl-CoA carboxylase - A review.

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Pathways

Oxidation of Odd-Chain Fatty Acid

Description:

References:

Effects of odd-numbered medium-chain fatty acids on the accumulation of long-chain 3-hydroxy-fatty acids in long-chain L-3-hydroxyacyl CoA dehydrogenase and mitochondrial trifunctional protein deficient skin fibroblasts.

Propionyl-CoA carboxylase - A review.

Databases

Tools

Institutional License

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