Pathways
Oxidation of Polyunsaturated Fatty Acid
Description:
Unsaturated fatty acids are Beta-oxidized in the normal pathway as far as possible. However, polyunsaturation or unsaturation at odd positions produces a molecule that the major pathways cannot utilize as a substrate. To solve this problem, a number of enzymes exist in the peroxisome to convert these molecules to appropriate substrates which can be shuttled into the normal pathway. Peroxisomes are capable of oxidizing a variety of substrates including polyunsaturated Enoyl-CoA esters. The Beta-Oxidation of unsaturated En...
References:
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Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease.
Front Mol Neurosci. 2018 Jan 23;11:10. doi: 10.3389/fnmol.2018.00010. eCollection 2018. Review. -
The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2.
J Biol Chem. 2010 Jul 30;285(31):24066-77. doi: 10.1074/jbc.M110.106005. Epub 2010 May 12. -
Biotransformations utilizing β-oxidation cycle reactions in the synthesis of natural compounds and medicines.
Int J Mol Sci. 2012 Dec 5;13(12):16514-43. doi: 10.3390/ijms131216514. Review.
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