Pathways
P2Y Receptor Signaling
Description:
Angiogenesis plays an important role in pathological events such as tumor growth, wound healing, psoriasis, and the ischemic retinopathies that occur in diabetes and sickle cell disease. The main modulators of the angiogenesis process in adults, is achieved through signaling by peptide growth factors, however, recent researches also emphasize the contribution of purines and pyrimidines to this process. Synergistic actions of purines and pyrimidines with growth factors aid in promoting cell proliferation (Ref.1). ATP (Adenos...
References:
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Involvement of P2Y receptors in the differentiation of haematopoietic cells.
J Leukoc Biol. 2003 Apr; 73(4): 442-7. Review. -
Purinergic signalling and immune cells.
Purinergic Signal. 2014 Dec;10(4):529-64. doi: 10.1007/s11302-014-9427-2. Epub 2014 Oct 29. Review. -
P2Y (2) receptor agonists: a new class of medication targeted at improved mucociliary clearance.
Chest. 2002 May; 121(5 Suppl): 201S-205S. Review. -
P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation.
Int J Mol Sci. 2020 Feb 19;21(4). pii: E1391. doi: 10.3390/ijms21041391. Review.
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