Pathways
p38 Signaling
Description:
P38s are a class of mitogen-activated protein kinases(MAPKs) are involved in cell differentiation, apoptosis and autophagy MAPKs are a family of Serine/threonine kinases that comprise 3 major subgroups, namely, ERK (Extracellular signal–Regulated Kinase), p38 MAPK and JNK (c-Jun N-terminal Kinases). Despite the diversity in function and upstream signaling events, MAPKs are always activated by a highly conserved mechanism that involves phosph...
References:
-
The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer.
Expert OpinInvestig Drugs. 2009 Dec;18(12):1893-905. doi: 10.1517/13543780903321490. Review. -
The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.
ActaCrystallogr D BiolCrystallogr. 2015 Apr;71(Pt 4):790-9. doi: 10.1107/S1399004715001212. Epub 2015 Mar 26. -
The regulatory role of activating transcription factor 2 in inflammation.
Mediators Inflamm. 2014;2014:950472. doi: 10.1155/2014/950472. Epub 2014 Jun 23. Review. -
TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease.
Kidney Res ClinPract. 2012 Jun;31(2):94-105. doi: 10.1016/j.krcp.2012.04.322. Epub 2012 Apr 26. Review.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions