Pathways
p53 Mediated Apoptosis
Description:
P53, the most extensively studied tumor suppressor, is a regulative factor of many processes necessary for the proper functioning of cells, and it corresponds to a number of processes associated with its life and death. The p53 protein regulates the repair of cellular DNA and induces apoptosis when the damage of the gene is too serious and it is impossible to repair. P53 can be activated by DNA damage, hypoxia, or aberrant oncogene expression to promote cell-cycle checkpoints, DNA repair, cellular senescence, and apoptosis (R...
References:
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P53 protein in proliferation, repair and apoptosis of cells.
Protoplasma. 2014 May;251(3):525-33. doi: 10.1007/s00709-013-0548-1. Epub 2013 Sep 17. -
Control of apoptosis by p53.
Oncogene. 2003 Dec 8;22(56):9030-40. Review. -
The role of p53 in apoptosis.
Discov Med. 2010 Feb;9(45):145-52. Review. -
p53 Family: Role of Protein Isoforms in Human Cancer.
J Nucleic Acids. 2012;2012:687359. doi: 10.1155/2012/687359. Epub 2011 Oct 9.
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