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Pathways

p53 Mediated Apoptosis

Description:

P53, the most extensively studied tumor suppressor, is a regulative factor of many processes necessary for the proper functioning of cells, and it corresponds to a number of processes associated with its life and death. The p53 protein regulates the repair of cellular DNA and induces apoptosis when the damage of the gene is too serious and it is impossible to repair. P53 can be activated by DNA damage, hypoxia, or aberrant oncogen[...]

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