Pathways
P53 Signaling
Description:
p53 is a tumour suppressor protein that regulates the expression of a wide variety of genes involved in Apoptosis, Growth arrest, Inhibition of cell cycle progression, Differentiation and accelerated DNA repair or Senescence in response to Genotoxic or Cellular Stress. As a transcription factor, p53 is composed of an N-terminal Activation Domain, a central specific DNA Binding Domain, and a C-terminal Tetramerization Domain, followed by a Regulatory Domain rich in basic Amino acids. Having a short half-life, p53 is normally m...
References:
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Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome.
Int J Mol Sci. 2017 Apr 28;18(5). pii: E928. doi: 10.3390/ijms18050928. Review. -
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.
Oncogene. 2014 Sep 18;33(38):4685-96. doi: 10.1038/onc.2013.413. Epub 2013 Oct 14. -
Reciprocal influence of the p53 and the hypoxic pathways.
Cell Death Dis. 2011 May 26;2:e164. doi: 10.1038/cddis.2011.48. Review. -
Multiple Functions of Protein Inhibitor of Activated STAT1 in Regulating Endothelial Cell Proliferation and Inflammation.
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1717-9. doi: 10.1161/ATVBAHA.116.308131. No abstract available.
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