p70-S6K Signaling

Description:

p70S6K is a protein Ser-Thr kinase that phosphorylates the ribosomal S6 subunit, a component of the 40S subunit of eukaryotic ribosomes. It plays a role in protein synthesis and in cell growth control during G1 phase in vivo to enhance translation of certain mRNA species (Ref.1). In the living cell, ribosomal p70S6K is activated through a complex network of signaling molecules. Multiple phosphorylation events within the catalytic, auto inhibitory and hydrophobic motif domains contribute to the reg...

References:

The S6K protein family in health and disease.
Tavares MR, Pavan IC, Amaral CL, Meneguello L, Luchessi AD, Simabuco FM.
Life Sci. 2015 Jun 15;131:1-10. doi: 10.1016/j.lfs.2015.03.001. Epub 2015 Mar 26. Review.
Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.
Sunami T, Byrne N, Diehl RE, Funabashi K, Hall DL, Ikuta M, Patel SB, Shipman JM, Smith RF, Takahashi I, Zugay-Murphy J, Iwasawa Y, Lumb KJ, Munshi SK, Sharma S.
J Biol Chem. 2010 Feb 12;285(7):4587-94. doi: 10.1074/jbc.M109.040667. Epub 2009 Oct 28.
Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors.
Endo M, Yamamoto H, Setsu N, Kohashi K, Takahashi Y, Ishii T, Iida K, Matsumoto Y, Hakozaki M, Aoki M, Iwasaki H, Dobashi Y, Nishiyama K, Iwamoto Y, Oda Y.
Clin Cancer Res. 2013 Jan 15;19(2):450-61. doi: 10.1158/1078-0432.CCR-12-1067. Epub 2012 Dec 3.
mTOR at the nexus of nutrition, growth, ageing and disease.
Liu GY, Sabatini DM.
Nat Rev Mol Cell Biol. 2020 Apr;21(4):183-203. doi: 10.1038/s41580-019-0199-y. Epub 2020 Jan 14. Review. Erratum in: Nat Rev Mol Cell Biol. 2020 Jan 31;:.

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Pathways

p70-S6K Signaling

Description:

References:

The S6K protein family in health and disease.

Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.

Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors.

mTOR at the nexus of nutrition, growth, ageing and disease.

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Institutional License

Pathways

p70-S6K Signaling

Description:

References:

The S6K protein family in health and disease.

Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.

Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors.

mTOR at the nexus of nutrition, growth, ageing and disease.

Databases

Tools

Institutional License

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