Pathways
PACAP Signaling
Description:
G Protein-coupled Receptors (GPCRs) based on sequence and structural similarities have been divided into five major classes: Rhodopsin (class A), Secretin (class B), Glutamate (class C), Adhesion, and Frizzled/Taste. A number of critical regulatory peptides, such as corticotropin-releasing hormone, calcitonin gene-related peptide, parathyroid hormone, glucagon, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) activate the Rhodopsin (class A) GPCRs. These regulatory peptides ar...
References:
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Targeting the PAC1 Receptor for Neurological and Metabolic Disorders.
Curr Top Med Chem. 2019;19(16):1399-1417. doi: 10.2174/1568026619666190709092647. Review. -
VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair.
Br J Pharmacol. 2013 Jun;169(3):512-23. doi: 10.1111/bph.12181. Review. -
Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity.
Front Endocrinol (Lausanne). 2013;4:55. Published 2013 May 21. doi:10.3389/fendo.2013.00055 -
Pituitary adenylate cyclase activating peptide (PACAP) participates in adipogenesis by activating ERK signaling pathway.
PLoS One. 2013;8(9):e72607. Published 2013 Sep 9. doi:10.1371/journal.pone.0072607
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