Pathways
PAK Signaling in Fission Yeast
Description:
Simple eukaryotes such as yeasts and molds encode multiple PAKs (p21-Activated Kinases) that, like their orthologs in other systems, act downstream of Rho-family GTPases. All PAKs contain an N-terminal PBD (p21 GTPase-Binding-Domain), which confers binding to small GTPases such as CDC42 (Cell Division Cycle-42) or Rac, and a C-terminal protein kinase domain, but they do not bind to Rho, Ras, or other small G-proteins. CDC42 and Rac bind in a GTP-dependent fashion to a highly conserved sequence, referred to as the CRIB (CDC42 ...
References:
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Rho GTPases: regulation of cell polarity and growth in yeasts.
Biochem J. 2010 Feb 24;426(3):243-53. doi: 10.1042/BJ20091823. -
PAK family kinases: Physiological roles and regulation.
Cell Logist. 2012 Apr 1;2(2):59-68. doi: 10.4161/cl.21912. -
The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe.
J Biol Chem. 2003 Dec 5; 278(49):48821-30. Epub 2003 Sep 23. -
The Cdc42 binding and scaffolding activities of the fission yeast adaptor protein Scd2.
J Biol Chem. 2003 Jan 10; 278(2):843-52. Epub 2002 Oct 29.
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