Pathways
Pancreatic Adenocarcinoma
Description:
Pancreatic carcinoma is one of the most enigmatic and aggressive malignant diseases. Neoplasms of the pancreas encompass a wide spectrum of benign and malignant tumors. Pancreatic adenocarcinoma, the malignant neoplasm of the exocrine duct cells, accounts for more than ninety percent of all pancreatic tumors (Ref.1). Pancreatic ductal adenocarcinoma evolves from a progressive cascade of cellular, morphological and architectural changes from normal ductal epithelium through pre-neoplastic lesions termed PanIN (Pancreatic Intra...
References:
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Addressing the challenges of pancreatic cancer: future directions for improving outcomes.Pancreatology
Epub 2015 Jan-Feb;15(1):8-18. doi: 10.1016/j.pan.2014.10.001. 2014 Oct 17. Review. -
Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.
Pelosi 2017 Nov 18;5(4). pii: E65. doi: 10.3390/biomedicines5040065. Review. -
Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer.
Int J Biol Sci. 2016 Jan 28;12(3):292-301. doi: 10.7150/ijbs.14995. eCollection 2016. Review. -
HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growthfactor beta.
Cancer Res. 2006 Oct 1;66(19):9591-600.
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