Pathogenesis of ALS

Description:

ALS (Amyotrophic Lateral Sclerosis), also known as Lou Gehrig’s disease, is a devastating neurodegenerative disorder, which is characterized by the selective degeneration of upper and lower motor neurons, the large nerve cells connecting the brain to the spinal cord and from the spinal cord to muscles, which control muscle movement. The loss of motor neurons leads to progressive atrophy of skeletal muscles. ALS is a relentless disease that manifests as progressive decline in muscular function resulting in eventual paral...

References:

Amyotrophic Lateral Sclerosis: New Perpectives and Update.
Orsini M, Oliveira AB, Nascimento OJ, Reis CH, Leite MA, de Souza JA, Pupe C, de Souza OG, Bastos VH, de Freitas MR, Teixeira S, Bruno C, Davidovich E, Smidt B.
Neurol Int. 2015 Sep 24;7(2):5885. doi: 10.4081/ni.2015.5885. eCollection 2015 Sep 24. Review.
ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad.
Kaus A, Sareen D.
Front Cell Neurosci. 2015 Nov 19;9:448. doi: 10.3389/fncel.2015.00448. eCollection 2015. Review.
Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.
Ayers JI, Diamond J, Sari A, Fromholt S, Galaleldeen A, Ostrow LW, Glass JD, Hart PJ, Borchelt DR.
Acta Neuropathol. 2016 Dec;132(6):827-840. Epub 2016 Oct 4.
A Turkish Family with a Familial ALS-positive UBQLN2-S340I Mutation.
Kotan D, Iskender C, Özoğuz Erimiş A, Başak AN.
Noro Psikiyatr Ars. 2016 Sep;53(3):283-285. doi: 10.5152/npa.2016.12371. Epub 2016 Sep 1. No abstract available.

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Pathways

Pathogenesis of ALS

Description:

References:

Amyotrophic Lateral Sclerosis: New Perpectives and Update.

ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad.

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.

A Turkish Family with a Familial ALS-positive UBQLN2-S340I Mutation.

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Pathogenesis of ALS

Description:

References:

Amyotrophic Lateral Sclerosis: New Perpectives and Update.

ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad.

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.

A Turkish Family with a Familial ALS-positive UBQLN2-S340I Mutation.

Databases

Tools

Institutional License

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