Pathogenesis of Gliomas

Description:

Tumors of the Central Nervous System (CNS) are devastating as they are difficult to treat and may cause grave disability or death. CNS Gliomas pose particularly difficult problems because of their tendency toward malignancy, rate of tumor spread, and the lack of effective therapy. Gliomas are the most common intracranial malignant tumors in humans (Ref.1). In vertebrates, the embryonic neural tube (neuroectoderm) gives rise [...]

References:

Molecular biology of gliomas: present and future challenges.
Altieri R, Agnoletti A, Quattrucci F, Garbossa D, Calamo Specchia FM, Bozzaro M, Fornaro R, Mencarani C, Lanotte M, Spaziante R, Ducati A.
Transl Med UniSa. 2014 Apr 8;10:29-37. eCollection 2014 Sep. Review.
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW.
Acta Neuropathol. 2016 Jun;131(6):803-20. doi: 10.1007/s00401-016-1545-1. Epub 2016 May 9. Review.
Genetic pathways to primary and secondary glioblastoma.
Ohgaki H, Kleihues P.
Am J Pathol. 2007 May;170(5):1445-53. Review.
Oligodendroglioma: pathology, molecular mechanisms and markers.
Wesseling P, van den Bent M, Perry A.
Acta Neuropathol. 2015 Jun;129(6):809-27. doi: 10.1007/s00401-015-1424-1. Epub 2015 May 6. Review.
Glioblastoma Multiforme Oncogenomics and Signaling Pathways.
Kanu OO, Hughes B, Di C, Lin N, Fu J, Bigner DD, Yan H, Adamson C.
Clin Med Oncol. 2009 Apr 8;3:39-52.
A deletion causing NF2 exon 9 skipping is associated with familial autosomal dominant intramedullary ependymoma.
Zemmoura I, Vourc'h P, Paubel A, Parfait B, Cohen J, Bilan F, Kitzis A, Rousselot C, Parker F, François P, Andres CR.
Neuro Oncol. 2014 Jan;16(2):250-5. doi: 10.1093/neuonc/not165. Epub 2013 Dec 18.
Insights into molecular therapy of glioma: current challenges and next generation blueprint.
Rajesh Y, Pal I, Banik P, Chakraborty S, Borkar SA, Dey G, Mukherjee A, Mandal M.
Acta Pharmacol Sin. 2017 May;38(5):591-613. doi: 10.1038/aps.2016.167. Epub 2017 Mar 20. Review.
Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date.
Bastien JI, McNeill KA, Fine HA.
Cancer. 2015 Feb 15;121(4):502-16. doi: 10.1002/cncr.28968. Epub 2014 Sep 23. Review.
Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features.
Karsy M, Gelbman M, Shah P, Balumbu O, Moy F, Arslan E.
Folia Neuropathol. 2012;50(4):301-21. Review.
The molecular characterization and clinical management of multiple myeloma in the post-genome era.
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Leukemia. 2009 Nov;23(11):1941-56. doi: 10.1038/leu.2009.160. Epub 2009 Aug 6. Review.

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Pathways

Pathogenesis of Gliomas

Description:

References:

Molecular biology of gliomas: present and future challenges.

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

Genetic pathways to primary and secondary glioblastoma.

Oligodendroglioma: pathology, molecular mechanisms and markers.

Glioblastoma Multiforme Oncogenomics and Signaling Pathways.

A deletion causing NF2 exon 9 skipping is associated with familial autosomal dominant intramedullary ependymoma.

Insights into molecular therapy of glioma: current challenges and next generation blueprint.

Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date.

Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features.

The molecular characterization and clinical management of multiple myeloma in the post-genome era.

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Pathogenesis of Gliomas

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