Pathways
Pathogenesis of Gliomas
Description:
Tumors of the Central Nervous System (CNS) are devastating as they are difficult to treat and may cause grave disability or death. CNS Gliomas pose particularly difficult problems because of their tendency toward malignancy, rate of tumor spread, and the lack of effective therapy. Gliomas are the most common intracranial malignant tumors in humans (Ref.1). In vertebrates, the embryonic neural tube (neuroectoderm) gives rise to the main cell types of the CNS, including neurons, astrocytes, oligodendrocytes and ependymal cells....
References:
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Molecular biology of gliomas: present and future challenges.
Transl Med UniSa. 2014 Apr 8;10:29-37. eCollection 2014 Sep. Review. -
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
Acta Neuropathol. 2016 Jun;131(6):803-20. doi: 10.1007/s00401-016-1545-1. Epub 2016 May 9. Review. -
Genetic pathways to primary and secondary glioblastoma.
Am J Pathol. 2007 May;170(5):1445-53. Review. -
Oligodendroglioma: pathology, molecular mechanisms and markers.
Acta Neuropathol. 2015 Jun;129(6):809-27. doi: 10.1007/s00401-015-1424-1. Epub 2015 May 6. Review.
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