Pathways
Pathogenesis of Helicobacter pylori Infection
Description:
The gastrointestinal tract represents an important barrier between human hosts and microbial populations. One potential consequence of host-microbial interactions is the development of mucosal inflammation. A paradigm for such chronic host-microbial relationships is carriage of Helicobacter pylori, Gram-negative bacteria that colonize the stomachs of humans and primates. H. pylori colonization induces chronic gastritis in essentially all hosts, a process that increases the risk of developing peptic ulceration, distal gastric ...
References:
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Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission.
Trends Microbiol. 2017 Apr;25(4):316-328. doi: 10.1016/j.tim.2016.12.004. Epub 2017 Jan 3. -
The impacts of H. pylori virulence factors on the development of gastroduodenal diseases.
J Biomed Sci. 2018 Sep 11;25(1):68. doi: 10.1186/s12929-018-0466-9. -
Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system.
Future Microbiol. 2015;10(6):955-65. doi: 10.2217/fmb.15.32. -
Helicobacter pylori Virulence Factors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment
Cells. 2020 Dec 25;10(1):27. doi: 10.3390/cells10010027.
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