Pathways
Pathogenesis of Multiple Sclerosis
Description:
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system that affects both adults and children. MS is characterized by the formation of multiple lesions along the nerve fibers in the brain, spinal cord and optic nerves. Inflammation of the white and gray matter tissues in the CNS due to focal immune cell infiltration and their cytokines are the incipient cause of damage in MS. Hallmark to MS is the demyelinated plaque, which consists of a well-demarcated hypocellul...
References:
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Initial immunopathogenesis of multiple sclerosis: innate immune response.
Clin Dev Immunol. 2013;2013:413465. doi: 10.1155/2013/413465. Epub 2013 Sep 24. Review. -
Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging.
Lancet Neurol. 2014 Aug;13(8):807-22. doi: 10.1016/S1474-4422(14)70101-2. Epub 2014 Jul 6. Review. -
Initial immunopathogenesis of multiple sclerosis: innate immune response.
Clin Dev Immunol. 2013;2013:413465. doi: 10.1155/2013/413465. Epub 2013 Sep 24. Review. -
Multiple sclerosis: pathogenesis and treatment.
Curr Neuropharmacol. 2011 Sep;9(3):409-16. doi: 10.2174/157015911796557911.
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