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Pathogenesis of Multiple Sclerosis


Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system that affects both adults and children. MS is characterized by the formation of multiple lesions along the nerve fibers in the brain, spinal cord and optic nerves. Inflammation of the white and gray matter tissues in the CNS due to focal immune cell infiltration and their cytokines are the incipient cause of damage in MS. Hallmark to MS is the demyelinated plaque, which consists of a well-demarcated hypocellul...




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