Pathways
Pathophysiology of Cerebral Ischemia
Description:
Cerebral ischemia (a type of Stroke) is a result of insufficient blood flow to the brain. It is a cerebrovascular disease that arises from arterial defects in the brain. It is the most common life-threatening neurological disease. It leads to limited supply of oxygen and other nutrients to meet metabolic demands. There are two types of cerebral ischemia: focal and global ischemia. Cerebral ischemia can lead to (1) cognitive impairments, (2) neuronal signalling failures, (3) pathophysiological chan...
References:
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Insights into the neuropathology of cerebral ischemia and its mechanisms.
Rev Neurosci. 2020 Jul 28;31(5):521-538. doi: 10.1515/revneuro-2019-0099. -
Yang JL, Mukda S, Chen SD.
Redox Biol. 2018 Jun;16:263-275. doi: 10.1016/j.redox.2018.03.002. Epub 2018 Mar 9. -
Apoptotic mechanisms after cerebral ischemia.
Stroke. 2009 May;40(5):e331-9. doi: 10.1161/STROKEAHA.108.531632. Epub 2009 Jan 29. -
Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia.
Neurochem Res. 2004 Nov;29(11):1943-9. doi: 10.1007/s11064-004-6869-x.
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