Pathways
Pathophysiology of GVHD
Description:
GVHD (Graft-Versus-Host Disease) is the main complication after allogeneic SCT (Stem Cell Transplantation) and induced by donor T cells in the graft. As in physiological T cell responses, alloreactive T cells depend on their activation by APCs (Antigen Presenting Cells). Potential APCs are B cells, monocytes/macrophages,and mainly dendritic cells (DC), the most efficient cells in antigen uptake, processing, and presentation on HLA class I and class II molecules. In HLA-mismatched SCT, HLA molecules are recognized directly by ...
References:
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Danger Signals and Graft-versus-host Disease: Current Understanding and Future Perspectives.
Front Immunol. 2016 Nov 29;7:539. eCollection 2016. Review. -
Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.
Nat Rev Immunol. 2007 Aug;7(8):585-98. Review. -
How I treat chronic graft-versus-host disease.
Blood. 2001 Mar 1;97(5):1196-201. Review. -
Pathophysiology of acute graft-versus-host disease.
Hematol Oncol. 2003 Dec;21(4):149-61. Review.
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