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Pathways

Pathways Regulating Alcoholism

Description:

Ethanol is a psychoactive substance with rewarding and sedative-hypnotic properties that stem largely from its acute effects on specific signaling proteins that lead to changes in localization and post-translational modifications, gene expression and neuronal excitability. Neurons adapt to repeated ethanol exposure through homeostatic changes in cellular signaling pathways that serve to maintain nervous system function in the presence of ethanol. The STOP and GO intracellular signaling pathways control alcohol drinking behavi...

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