Pathways
Paxillin Interactions
Description:
Signals that derive from cell adhesion to the ECM (Extracellular Matrix) regulate important physiological events including cell motility and growth, and most often involve changes in the organization of the actin cytoskeleton. Cells interact with the ECM via transmembrane receptors, termed integrins, located at the cell surface. Binding of integrins to the ECM is accompanied by a localized clustering of these receptors, with the subsequent recruitment of structural and signaling molecules to the sites of matrix attachment,...
References:
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Structural and mechanical functions of integrins.
Biophys Rev. 2014 Jun;6(2):203-213. doi: 10.1007/s12551-013-0124-0. Epub 2013 Oct 8. Review. -
Paxillin: a crossroad in pathological cell migration.
J Hematol Oncol. 2017 Feb 18;10(1):50. doi: 10.1186/s13045-017-0418-y. Review. -
Focal adhesion regulation of cell behavior.
Biochim Biophys Acta. 2004 Jul 5;1692(2-3):103-19. Review. -
MAP kinases and cell migration.
J Cell Sci. 2004 Sep 15;117(Pt 20):4619-28. Review.
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