Pathways
PDGF Pathway
Description:
PDGF (Platelet-derived growth factor) isoforms stimulate growth, survival and motility of mesenchymal cells and certain other cell types. They have important functions during embryonal development and in the control of tissue homeostasis in the adult. Overactivity of PDGF signaling is associated with the development of certain malignant diseases, as well as non-malignant diseases characterized by excessive cell proliferation. The PDGF isoforms are synthesized as precursor molecules with signal sequences, precursor sequences a...
References:
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Targeting the PDGF signaling pathway in tumor treatment.
Cell Commun Signal. 2013 Dec 20; 11:97. doi: 10.1186/1478-811X-11-97. Review. -
Roles of PDGF in animal development.
Development. 2003 Oct; 130(20):4769-84. Review. -
PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review).
Mol Med Rep. 2017 Dec; 16(6):7879-7889. doi: 10.3892/mmr.2017.7641. Epub 2017 Sep 27. Review. -
New molecular insights into peripheral T cell lymphomas.
J Clin Invest. 2012 Oct; 122(10):3448-55. doi: 10.1172/JCI61205. Epub 2012 Oct 1. Review.
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