Pathways
Pharmacokinetics of STATIN in Liver
Description:
Cholesterol is the key component of the structure and function of cell membranes and is biosynthesized by all animal cells. Cholesterol biosynthesis occurs in the liver and the intestines. The liver has two sources of cholesterol either it can take up LDL particles from the blood, or it can synthesis cholesterol using HMG-CoA reductase adding to the cholesterol pool in the liver cell. Cholesterol, owing to their hydrophilic structure are packed within lipoproteins for intra cellular transport. Se...
References:
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Intolerance to statins: mechanisms and management.
Diabetes Care. 2013 Aug;36 Suppl 2:S325-30. doi: 10.2337/dcS13-2038. Review. No abstract available. -
Repurposing of statins via inhalation to treat lung inflammatory conditions.
Adv Drug Deliv Rev. 2018 Aug;133:93-106. doi: 10.1016/j.addr.2018.06.005. Epub 2018 Jun 8. Review. -
Statins: a viable candidate for host-directed therapy against infectious diseases.
Nat Rev Immunol. 2019 Feb;19(2):104-117. doi: 10.1038/s41577-018-0094-3. Review. -
Statin-induced myopathy: a review and update.
Expert Opin Drug Saf. 2011 May;10(3):373-87. doi: 10.1517/14740338.2011.540568. Epub 2011 Feb 23. Review.
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