Pathways
Phosphatidylcholine Biosynthesis in S. cerevisiae
Description:
PC (Phosphatidylcholine) is the most abundant Phospholipid in the yeast S. cerevisiae (Saccharomyces cerevisiae) and the major Phospholipid present in eucaryotic cell membranes. It serves as a major structural component of cellular membranes and as a source of several lipid messengers. There are two pathways for PC synthesis in yeast, the CDP-Choline (Cytidine Diphosphate-Choline) pathway (a part of Kennedy Pathway) and the CDP-DAG (Cytidine Diphosphate-Diacylglycerol). Both pathways function to synth...
References:
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Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae.
J. Biol. Chem. 2005 Jul 21. -
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
Biochim. Biophys. Acta. 2004 Nov 8;1686(1-2):161-8. -
Phospholipid synthesis in yeast: regulation by phosphorylation.
Biochem. Cell Biol. 2004 Feb;82(1):62-70. -
Regulation of the DPP1-encoded diacylglycerol pyrophosphate (DGPP) phosphatase by inositol and growth phase. Inhibition of DGPP phosphatase activity by CDP-diacylglyceron and activation of phosphatidylserine synthase activity by DGPP.
J. Biol. Chem. 2000 Dec 29;275(52):40887-96.
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