Pathways
Phospholipase-C Pathway
Description:
Inositol lipid-specific PLC (Phospholipase-C) isozymes are key signaling proteins in the cellular action of many hormones, neurotransmitters, growth factors, and other extracellular stimuli. PLC are soluble proteins that are partly cytosolic and partly associated with membrane. The PLC family in human is comprised of 13 subtypes. On the basis of their structure, they have been divided into six classes, PLC-Beta (Beta 1, 2, 3 and 4), PLC-Gamma (Gamma 1 and 2), PLC-Delta (Delta 1, 3 and 4), PLC-Epsilon, PLC-Zeta and PLC-Eta (...
References:
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Mechanism of activation and inactivation of Gq/phospholipase C-ß signaling nodes.
Chem Rev. 2011 Oct 12;111(10):6120-9. doi: 10.1021/cr200209p. No abstract available. -
PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands.
Chem Senses. 2005 Sep;30(7):593-600. Epub 2005 Aug 31. -
Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction.
Histol Histopathol. 2005 Oct;20(4):1251-60. -
Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling.
Trends Biochem Sci. 2005 Dec;30(12):688-97. Epub 2005 Nov 2.
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