Pathways
PI3K Signaling in Caenorhabditis elegans
Description:
PI3Ks (Phosphoinositide 3-Kinases) are an important type of lipid kinase that form a large evolutionarily conserved family of enzymes that specifically phosphorylate inositol phospholipids at the D-3 position of the inositol ring. The C. elegans (Caenorhabditis elegans) PI3K is required for functional membrane trafficking machinery (Ref.1). C. elegans PI3K adaptor subunit aap-1 (Phosphoinositide 3-Kinase age-1 Adapter Subunit-58.5 KD) shares moderate sequence similarity with the p50/p55 adaptor subunits of their vertebra...
References:
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PI3K: from the bench to the clinic and back.
Curr Top Microbiol Immunol. 2010;347:1-19. doi: 10.1007/82_2010_65. Review. -
Exploring the role of two interacting phosphoinositide 3-kinases of Haemonchus contortus.
Parasit Vectors. 2014 Nov 12;7:498. doi: 10.1186/s13071-014-0498-2. -
pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans.
Aging Cell. 2011 Dec;10(6):1021-31. doi: 10.1111/j.1474-9726.2011.00747.x. -
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
Genes Dev. 1999 Jun 1; 13(11): 1438-52.
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