Pathways
PI3K Signaling in B-Lymphocyte
Description:
PI3Ks (Phosphoinositide-3-Kinases) regulate numerous biological processes, including cell growth, differentiation, survival, proliferation, migration and metabolism. In the immune system, impaired PI3K signaling leads to immunodeficiency, whereas unrestrained PI3K signaling contributes to autoimmunity and Leukemia. The Class I and III PI3Ks basically facilitate B-cell development through defined stages, resulting in at least three distinct lineages of mature B-lymphocytes. In B-cells, PI3K is activated within seconds of ...
References:
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Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation.
J Immunol. 2007 Feb 15;178(4):2328-35. -
The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.
J Leukoc Biol. 2010 Jun;87(6):1083-95. Epub 2010 Mar 3. -
Phosphoinositide 3-kinase-regulated adapters in lymphocyte activation.
Immunol Rev. 2009 Nov;232(1):255-72. Review. -
CD19: a biomarker for B cell development, lymphoma diagnosis and therapy.
Exp Hematol Oncol. 2012;1(1):36. Published 2012 Nov 29. doi:10.1186/2162-3619-1-36
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