PKC-Theta Pathway

Description:

An effective immune response depends on the ability of specialized immunocytes to identify foreign molecules and respond by differentiation into mature effector cells. A cell-surface antigen recognition apparatus and a complex intracellular receptor-coupled signal-transducing machinery mediate this tightly regulated process, which operate at hig...

References:

Protein kinase Ctheta: a new essential superstar on the T-cell stage.
Altman A, Isakov N, Baier G.
Immunol Today. 2000 Nov; 21(11): 567-73. Review.
The yin and yang of protein kinase C-theta (PKC?): a novel drug target for selective immunosuppression.
Zhang EY, Kong KF, Altman A.
Adv Pharmacol. 2013;66:267-312. doi: 10.1016/B978-0-12-404717-4.00006-8. Review.
Protein kinase C-theta; signaling from the center of the T-cell synapse.
Arendt CW, Albrecht B, Soos TJ, Littman DR.
Curr Opin Immunol. 2002 Jun; 14(3): 323-30. Review.
T cell Receptor Signal Transduction in T lymphocytes.
Gorentla BK, Zhong XP.
J Clin Cell Immunol. 2012 Oct 27;2012(Suppl 12):5.

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Pathways

PKC-Theta Pathway

Description:

References:

Protein kinase Ctheta: a new essential superstar on the T-cell stage.

The yin and yang of protein kinase C-theta (PKC?): a novel drug target for selective immunosuppression.

Protein kinase C-theta; signaling from the center of the T-cell synapse.

T cell Receptor Signal Transduction in T lymphocytes.

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Institutional License

Pathways

PKC-Theta Pathway

Description:

References:

Protein kinase Ctheta: a new essential superstar on the T-cell stage.

The yin and yang of protein kinase C-theta (PKC?): a novel drug target for selective immunosuppression.

Protein kinase C-theta; signaling from the center of the T-cell synapse.

T cell Receptor Signal Transduction in T lymphocytes.

Databases

Tools

Institutional License

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