Pathways
Pleiotropic Effects of STATIN
Description:
Statins are the most common drug used to treat hyperlipidemia. They also induce several pleiotropic effects like improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, and stabilization of atherosclerotic plaques. The different pleiotropic effects arise due to marked differences in lipophilicity, solubility and differential localization of statins which is based on the presence or absence of polar moieties on its hydrophobic structures. Lip...
References:
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Statins and the vascular endothelial inflammatory response.
Trends Immunol. 2007 Feb;28(2):88-98. Epub 2007 Jan 2. Review. -
Spectrum of pleiotropic effects of statins in heart failure.
Heart Fail Clin. 2008 Apr;4(2):153-61. doi: 10.1016/j.hfc.2008.01.007. Review. -
RhoA/Rho-Kinase in the Cardiovascular System.
Circ Res. 2016 Jan 22;118(2):352-66. doi: 10.1161/CIRCRESAHA.115.306532. Review. -
Effects of statins on endothelium and signaling mechanisms.
Stroke. 2004 Nov;35(11 Suppl 1):2708-11. Epub 2004 Sep 16. Review.
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