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Pathways

Pleiotropic Effects of STATIN

Description:

Statins are the most common drug used to treat hyperlipidemia. They also induce several pleiotropic effects like improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, and stabilization of atherosclerotic plaques. The different pleiotropic effects arise due to marked differences in lipophilicity, solubility and differential localization of statins which is based on the presence or absence of polar moieties on its hydrophobic structures. Lip...

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